What are the dissolution methods of hydroxypropyl methylcellulose HPMC?

A: Hot water dissolution method: Since HPMC does not dissolve in hot water, HPMC can be evenly dispersed in hot water at the initial stage, and then quickly dissolved when cooled. Two typical methods are described as follows：

1），Add 1/3 or 2/3 of the required amount of water into the container and heat it to 70°C. Disperse HPMC according to method 1) to prepare hot water slurry; then add the remaining amount of cold water to the hot water slurry, stir and cool the mixture.

Powder mixing method: HPMC powder is mixed with a large amount of other powdered ingredients in a mixer, and then water is added to dissolve. At this time, HPMC can be dissolved without agglomeration, because there is only a little HPMC powder in each tiny corner, which will dissolve immediately when it encounters water. ——Putty powder and mortar manufacturers use this method. Hydroxypropyl methyl cellulose (HPMC) is used as a thickener and water retaining agent in putty powder mortar.

2），Put the required amount of hot water in a container and heat it to about 70°C. Gradually add hydroxypropyl methylcellulose while stirring slowly. HPMC will float on the surface of the water at first, and then gradually form a slurry. Cool the slurry while stirring.